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Sigma
Fibrinopeptide A human
F3254 -
≥96% (HPLC)
DOWNLOAD MSDS (PDF)CAS Number: 25422-31-5
Empirical Formula (Hill Notation): C63H97N19O26
Molecular Weight: 1536.56
MDL number: MFCD00076437
PubChem Substance ID: 24894837
Properties
| Related Categories | Blood, Clotting Factors, Coagulation Proteins and Reagents, Extracellular Matrix Peptides (ECM), Fibrinogen, |
| assay | ≥96% (HPLC) |
| storage temp. | −20°C |
| Gene Information | Research your gene in Your Favorite Gene powered by Ingenuity human ... FGA(2243) |
Description
Amino Acid Sequence
Ala-Asp-Ser-Gly-Glu-Gly-A
Biochem/physiol Actions
Fibrin polymerization is initiated by thrombin cleavage of fibrinopeptide A from fibrinogen α chains, exposing two E domain E(A) sites. The phenylalanine at α chain residue 8 is important for efficient thrombin-catalyzed proteolysis of fibrinogen. Substitution of tyrosine for phenylalanine blocks sequential fibrinopeptide release and, thus, blocks polymerization and clot formation.
Price and Availability
Customers Also Viewed
50-70% protein (≥80% of protein is clottable)
Documents
Certificate of Analysis
Certificate of Origin
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Safety Information
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
Articles
Plasma Derived Proteins and Enzymes
Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Gas chromatography
References
Johnson, B.J. and May, W.P. J. Pharm. Sci. 58, 1568, (1969) Abstract
Rooney, M.M., Mullin, J.L., Lord, S.T., Substitution of tyrosine for phenylalanine in fibrinopeptide A results in preferential thrombin cleavage of fibrinopeptide B from fibrinogen. Biochemistry 37, 13704-13709, (1998) Abstract
Mosesson, M.W., Fibrinogen and fibrin polymerization: appraisal of the binding events that accompany fibrin generation and fibrin clot assembly. Blood Coag. Fibrinolysis 8, 257-267, (1997)
Weitz, J.I., Elevated fibrinopeptide A and B levels during thrombolytic therapy: real or artefactual. Thromb. Haemost. 75, 529-535, (1996) Abstract
Baker, E.S., et al., Simultaneous fragmentation of multiple ions using IMS drift time dependent collision energies. J. Am. Soc. Mass Spectrom. 19, 411-9, (2008) Abstract
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